Dopamite Science

Balance Your Mind & Your Body!

This mind-enhancing fat-loss secret is one of the fastest growing topics of discussion amongst scientists.

Isn’t it time you got in on it?

An area of your brain known as “the reward system” plays a critical role in regulating fat loss, losing weight and achieving the six pack set of abs you’ve always wanted. Below, we reveal the first weight management aid specifically intended to optimize the reward system and help you overcome your weight-loss struggles.

The Brain-Body Cycle of Weight Loss

For now, forget about “thermogenesis”, “beta-receptors”, “lipolysis” and all those other rehashed terms that marketers of conventional weight loss supplements use. It’s 2012.

The real truth of the matter is that weight loss begins and ends in the brain:

  • BRAIN → You wake up and go to bed feeling satisfied, motivated, confident and in charge. You’re driven to eat and exercise properly.
  • BODY → Now that you’re eating and exercising properly, you lose fat and appear leaner every day.
  • BRAIN → Seeing your body improve (and others reacting positively to it) causes you to feel even more satisfied, motivated, confident and in charge. Success is your new “addiction.”
  • BODY → The fat keeps dropping off of your body and your waist size alongside. The body you’ve always wanted (and others will want, too) is finally starting to emerge.
  • BRAIN → And so on…

The brain-body cycle of weight loss described above is one that few of us manage to initiate, let alone sustain. A growing body of scientific evidence suggests that the secret to overcoming your weight loss struggles lies inside the reward system of your brain.

For reasons described below, the reward system is also known as “the fat burning control center.” It is driven by a potent, naturally occurring substance known as dopamine. Simply stated, when dopamine and your reward system are in balance, so are you, literally and figuratively. Dieting for weight loss becomes a piece of cake!

Dopamine and the Reward System

Dopamine is the driving force of the reward system. The reward system regulates sensations of pleasure, satisfaction and motivation associated with food and other experiences. Temptations to eat originate within the reward system.

The single most powerful thing you can do to overcome your weight loss struggles is to avoid overeating. Nothing else will help you burn fat and lose weight as quickly.

That’s why the reward system is also known as “the fat burning control center”.

Dopamine is a neurotransmitter, a chemical that helps transmit messages between brain cells, or neurons. Your brain is essentially run by neurotransmitters. Among the most important of them are dopamine, serotonin, norepinephrine and epinephrine. Epinephrine, a.k.a. adrenaline, is produced by the adrenal gland. Upon release, it circulates to the brain where it stimulates mental performance so that you can quickly deal with stressful situations. It also helps regulate the breakdown, or lipolysis, of body fat.

Dopamine, a.k.a. “the pleasure chemical”, may be the most potent of all the neurotransmitters, particularly within the reward system. Perhaps that’s why a recent search of PubMed reveals that of the half dozen or so neurotransmitters most commonly mentioned in scientific papers, dopamine tops the list. In the last three years, research on it has taken off.

Billions upon billions of dopamine molecules can fit inside a single tablespoon. Despite its small size, it can throw a mighty punch. Indeed, when brain cells within the reward system release dopamine, the pleasure can be intoxicating.

The human brain is hard-wired to seek out “instant gratification” from pleasurable things, included among them food and sex. Much of this hard wiring is thought to reside in the reward system. One hundred and fifty thousand or so years ago, this helped us survive.
Today, opportunities for instant gratification surround us, including many calorie-rich, fattening foods. Needless to say, this creates a major barrier to weight loss.

Dieting and Dopamine

Brains cells in the reward system release dopamine in proportion to what scientists refer to as the “saliency” of the stimulus. A cheeseburger or a sugary soda can seem highly salient, depending on the circumstances! The brain sees these foods for what they are -rich sources of calories- and drives you to eat them, even when you don’t need any more calories.

Scientific research suggests that dysregulation, or imbalances, of dopamine in the reward system may contribute to the difficulty of dieting. Dieting often feels like holding yourself under water: You can barely wait to come up for air (food). Eventually you must, at which point the tendency is to hyperventilate (binge, or overeat). Restoring the balance of dopamine in the reward system may reduce the risk of this.

Below, an assortment of scientists talk about how imbalances of dopamine or dopaminergic (dopamine-related) function in the reward system may contribute to overeating and weight gain:
“…it has been postulated that dopamine dysregulation contributes to the development of obesity and binge-eating (Davis et al., 2009; Mathes et al., 2010).” (from Niswender et al., 2011)

“The involvement of dopamine signaling in the regulation of food intake has been clearly established [3]. Its major functions are related to motivation and reward and involvement in salience attribution to food. Food intake induces a dopamine release in the striatum thereby exerting its rewarding effect [18]. This is similar to the effects of drug abuse [19], suggesting parallels between obesity and drug addiction [3]. Part of the aetiology of both conditions could be explained by a hypodopaminergic mesolimbic system that leads to increased motivation for food and drugs, respectively [3].” (from de Weijer et al., 2011)

“Long recognized as an important mediator of feeding behavior, dopamine signaling is increasingly of interest . . . with findings that dopamine D2 receptor binding is reduced in a BMI-dependent manner (Wang et al, 2001). Building on this observation, current models of . . . dopaminergic dysfunction, referred to as hypodopaminergic reward deficiency syndrome (HRDS), has a predisposing and/or causative role (Wang et al, 2001).

We propose that intact insulin signaling in dopamine-rich brain regions supports dopamine homeostasis and normal reward for food. In our modern, energy-dense food environment, reward drives poor dietary decisions where reward-driven overconsumption of high-fat, high-sugar, energy-dense foods quickly leads to neuronal insulin resistance, dysregulation of dopamine homeostasis, and HRDS. This ‘syndrome’ results in chronically increased intake of fat and sugar to achieve a normal level of reward in the setting of decreased dopamine tone.”
(from de Weijer et al., 2011)

DOPAMITE™: A new era in weight management aids.

The exploding body of scientific evidence about dopamine and the reward system suggested to MHP researchers that a new type of weight-loss technology was necessary. When they looked at the current crop of weight loss products, they realized that dopamine was for the most part being overlooked. Greater attention was being given to thermogenesis, lipolysis, beta-receptors and other factors. All of these play roles in mediating weight loss, though not necessarily to the extent so often suggested. However, dopamine is in its own league.

The technology that MHP envisioned developing for consumers would support their body’s ability to correct or prevent dopamine and reward system imbalances, thereby catalyzing fat burning and weight loss. That technology is new DOPAMITE.
Help curb your desire for food and overcome your weight loss struggles!

DOPAMITE works by helping your body balance dopamine in the reward system of your brain, a.k.a. “the fat burning control center.” Simply stated, when dopamine and your reward system are in balance, so are you, literally and figuratively. With DOPAMITE, dieting for weight loss becomes a piece of cake!

By helping your body balance dopamine, DOPAMITE promotes normal healthy levels of energy, satisfaction, motivation and pleasure. The result: You’re less likely to seek out these sensations from food. This makes it easier to avoid overeating, burn fat, lose weight, and achieve the six pack set of abs you’ve always wanted.

Activate Your “Fat Burning Control Center” with this Groundbreaking 4-Process Formula!

The secret to DOPAMITE’s power is a unique 4-process formula:

  1. Process 1: DOPAMITE contains natural ingredients known as “pre-cursors” that support your body’s ability to produce, or synthesize, dopamine in the reward system as needed. These pre-cursors consist of particular types of amino acids. Amino acids are the building blocks of protein.
  2. Process 2: In order for the reward system to function properly, there must be a proper balance between the synthesis and breakdown of dopamine. DOPAMITE contains nutrients known as “co-factors” that your body requires to establish this balance.
  3. Process 3: Dopamine is known as a neurotransmitter. This means that it helps brain cells (a.k.a. neurons) transmit messages between (i.e. “talk” with) one another. Dopamine doesn’t act alone. Its balance depends on other neurotransmitters such as serotonin and norepinephrine. DOPAMITE contains natural ingredients that support these other neurotransmitters.
  4. Process 4: DOPAMITE contains Explotech Fast Release Technology. This proprietary, lab-tested delivery technology helps ensure that the ingredients in each DOPAMITE tablet are quickly and efficiently delivered to your body.

DOPAMITE Ingredient Highlights

DL-Phenylalanine (DLP) is added to DOPAMITE to support the body’s ability to balance dopamine and other neurotransmitters that it interacts with, including serotonin and norepinephrine.

DLP is a mixture the D- and L- isomers of the amino acid phenylalanine, found naturally in the diet. L-phenylalanine is a precursor to dopamine and other neurotransmitters whose actions affect the reward system. D-phenylalanine is believed to enhance mood, though its mechanisms of action are not clear.

DLP has been the focus of numerous clinical studies over the years due to its mood enhancing and soothing properties. For instance, in a double-blind clinical study comparing DLP vs. imipramine, a tricyclic anti-depressant, the authors of the study described DLP’s ability to positively affect mood as “substantial” (5). Scientists are still trying to determine how DLP works. While L-phenylalanine may act as a precursor, D-phenylalanine may reduce the breakdown of “painkillers”, known as endorphins, which are produced naturally by the body. Another possibility is that DLP increases brain levels of phenylethylamine (PEA). PEA is the substance believed to be responsible for the “feel good” effects of chocolate.

L-3,4-dihydroxyphenylalanine (L-DOPA) and Biologic Amines are supplied by the Ilex paraguariensis and Mucuna pruriens extracts, respectively, in DOPAMITE. Research suggests that both L-DOPA and Biologic Amines may enhance dopaminergic function.
Whereas dopamine itself cannot cross the blood-brain barrier, L-DOPA can. Once it reaches the reward system, it can be converted into dopamine as needed.

Like L-phenylalanine and L-DOPA, n-acetyl-tyrosine (NAT) acts as a neurotransmitter precursor. It can be converted into dopamine as well as norepinephrine. These conversions and other steps in dopamine metabolism require the presence of a variety of nutritional co-factors, including folic acid, copper and vitamin B12. All three of these co-factors are found in DOPAMITE. Collectively, they support the body’s ability to balance dopamine and reward system function.

The caffeine in DOPAMITE comes from caffeine anhydrous and Ilex paraguariensis extract. Caffeine is thought to enhance dopaminergic tone at least in part by blocking the actions of adenosine, another neurotransmitter. Caffeine can also increase epinephrine levels. When epinephrine is release into the bloodstream in large amounts, it creates a dramatically heightened sense of energy, alertness, strength and well-being, referred to as the “adrenaline rush”. This helps us conquer stressful challenges. Epinephrine also helps regulate the breakdown, or lipolysis, of body fat.

To support the fastest possible results, each tablet of DOPAMITE contains Explotech Fast Release Technology. This proprietary, lab-tested delivery technology helps ensure that the ingredients in each DOPAMITE tablet are quickly and efficiently delivered to your body.

Explotech contains a proprietary blend of ingredients known as superdisintegrants. As the term suggests, superdisintegrants accelerate tablet disintegration. In turn, this accelerates the release of the ingredients in the tablet. Lab tests conducted by the manufacturer reveal that the DOPAMITE tablet exceeds United States Pharmacopeia (USP) guidelines for tablet disintegration.

MHP researchers also added vinpocetine and theobromine to DOPAMITE. Both ingredients have the ability to relax, or dilate, blood vessels (vasodilation). When blood vessels in the brain relax, blood flow improves. This makes it easier to transport dopamine precursors and co-factors to the reward system where they can carry out their intended function.

Beckmann et al. (1979). Arch Psychiatr Nervenkr 227(1): 49.

Coates et al. (2011). Philos Trans R Soc Lond B Biol Sci 365(1538): 331. Available online at:

de Weijer et al. (2011). EJNMMI Res 1: 37. Available online at:
Erixon-Lindroth et al. (2005). Psychiatry Res, 138(1): 1.

Niswender et al. (2011). Neuropsychopharmacology 36(10: 359. Available online at:

Roelands and Meeusen (2011). Eur J Appl Physiol Aug 27. Received ahead of publication from author.
Thornley et al. (2011). Curr Neuropharmacol 9(2): 370.

Verbeken et al. (2011). Appetite Nov 23. (received ahead of publication from author)

Walton-Hadlock (2003). Medications of Parkinson’s Disease or Once Upon A Pill: Patient Experiences With Dopamine-enhancing Drugs and Suplpements. Pages 121-122. Available online at: